📄 Category

molecular biology

233 papers

Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.

On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.

Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.

📄 molecular biology

Local clocks within human tissues reveal widespread 24-hour rhythms in gene expression

By analyzing nearly 15,000 samples across 45 human tissues, this study reveals that local tissue clocks drive widespread 24-hour gene expression rhythms, uncovering a significantly larger extent of rhythmic transcription in the brain than previously known and identifying numerous disease-associated genes with distinct diurnal phases that offer new opportunities for chronotherapeutic interventions.

Palumaa, T., Cherry, J. M., Palta, P., Burns, A. C.2026-03-26
📄 molecular biology

Copper Import via CTR1 Supports the β3-Adrenergic Thermogenic Program

This study identifies copper importer CTR1 as a critical regulator of adaptive thermogenesis, demonstrating that its upregulation by cold exposure and β\beta3-adrenergic signaling is essential for maintaining copper homeostasis, mitochondrial oxidative capacity, and lipolytic activation to sustain thermogenic responses in adipose tissues.

Jeon, T.-I., Lee, Y.-S., Korolnek, T., Kim, J., Poudel, P., Bhattacharjee, P., Zhao, X., Ying, E., Liu, N., Xiao, T., Ch (…)2026-03-26
📄 molecular biology

FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNA

Using nanoscale imaging, this study reveals that FUS and TAF15 functionally compensate for the loss of EWSR1 by reorganizing into a similar ribonucleoprotein network to safeguard nascent RNA levels and cellular metabolic activity, highlighting critical functional redundancy within the FET protein family.

Sundara Rjan, S., Khan, I., Jones, T., Brownmiller, T., Ebegboni, V., Lim, L., Tran, A. D., Kruhlak, M., Caplen, N.2026-03-26
📄 molecular biology

Muscleblind-like proteins dimerize by forming disulfide bonds to regulate alternative splicing and pathogenic RNA foci formation

This study reveals that Muscleblind-like (MBNL) proteins dimerize via intermolecular disulfide bonds to regulate alternative splicing and maintain the structural integrity of pathogenic RNA foci in Myotonic Dystrophy Type 1.

Knudson, L. A., Kosti, A., Moss, K. R., Shi, L., Nguyen, G. N., Janusz-Kaminska, A., Zhou, E. X., Hildebrandt, R. P., Wa (…)2026-03-26
📄 molecular biology

Transmembrane domain composition reflects subcellular localization of SNARE proteins

By combining statistical analysis of 14,000 SNARE transmembrane domains with molecular dynamics simulations, this study reveals that distinct amino acid compositions—specifically bulky phenylalanine in early secretory pathways versus smaller isoleucine in late pathways—have evolved to optimize protein anchoring within the unique biophysical environments of different eukaryotic membranes.

Baumann, C., Pulido-Quetglas, C., Fasshauer, D.2026-03-25
📄 molecular biology

ProAR: Probabilistic Autoregressive Modeling for Molecular Dynamics

ProAR introduces a probabilistic autoregressive framework with a dual-network system and anti-drifting sampling strategy to generate flexible, long-length molecular dynamics trajectories that better capture time-dependent conformational diversity and reduce reconstruction errors compared to existing state-of-the-art methods.

Cheng, K., Liu, Y., Nie, Z., Lin, M., Hou, Y., Tao, Y., Liu, C., Chen, J., Mao, Y., Tian, Y.2026-03-21
📄 molecular biology

Pathogenic Leptospira in dogs and rodents in Tha Wang Pha, Thailand - Prevalence, diversity and linked environments

This study reveals that free-roaming dogs and diverse rodent species in rural Tha Wang Pha, Thailand, serve as reservoirs for multiple pathogenic *Leptospira* species, including the first confirmed detection of *L. weilii* in Thai rodents, highlighting a complex transmission cycle that bridges animal habitats and human settlements and underscores the need for integrated One Health surveillance.

Jaiwung, W., Dokhelar, T., Morand, S., Chaisiri, K., De Garine-Wichatitsky, M., Kritiyakan, A., Guernier-Cambert, V.2026-03-20